Preventing HIV cell entry There is no cure for AIDS ... viral strains carrying different maraviroc resistance–conferring mutations within gp120 have been observed both in cell culture ...

当病毒侵入人体时，HIV表面的gp120与宿主细胞表面的CD4受体结合，然后与CCR5或CXCR4辅助受体结合，促使gp41介导病毒包膜与细胞膜融合。融合后 ...

Furthermore, vaccine development faces huge problems, mainly because of the low antigenicity and immunogenicity of the HIV envelope glycoprotein gp120 and the efficient hiding of highly immunogenic ...

Researchers at the Vaccine Research Center (“VRC”) have determined the three-dimensional structure of the HIV-1 Envelope trimeric ectodomain (“Env”), comprised of three gp120 and three ...

他们观察到Nb457通过与CD4结合，诱导了CD4的D1结构域构象改变，从而有效地阻碍了HIV-1的gp120与CD4细胞的结合。同时，他们发现Nb457的表位位于MHC-II结合 ...

Determinants of HIV cell tropism & chemokine receptor usage The V3 loop of HIV-1 gp120 is a primary determinant of cell tropism and chemokine receptor usage, whereas the V1/V2 region is involved ...

The study shows that intact HIV and its viral envelope protein gp120 each cause macrophages, a type of white blood cell, to ...

VRC01 was shown around a decade ago to be one of several antibodies generated against the gp120 envelope glycoprotein binding CD4 (the main receptor for the HIV-1 virus), and one that achieves broad ...

This vaccine used a recombinant canarypox vaccine to prime immune responses plus protein subunits of the HIV surface protein (termed gp120) to boost immune responses. Further analysis of the data ...

David Baltimore (then at Rockefeller University and later MIT), we identified and functionally characterized the CD40 signaling molecule, TRAF-3. Our earlier research efforts in HIV contributed to ...