Preventing HIV cell entry There is no cure for AIDS ... viral strains carrying different maraviroc resistance–conferring mutations within gp120 have been observed both in cell culture ...

当病毒侵入人体时，HIV表面的gp120与宿主细胞表面的CD4受体结合，然后与CCR5或CXCR4辅助受体结合，促使gp41介导病毒包膜与细胞膜融合。融合后 ...

Researchers at the Vaccine Research Center (“VRC”) have determined the three-dimensional structure of the HIV-1 Envelope trimeric ectodomain (“Env”), comprised of three gp120 and three ...

他们观察到Nb457通过与CD4结合，诱导了CD4的D1结构域构象改变，从而有效地阻碍了HIV-1的gp120与CD4细胞的结合。同时，他们发现Nb457的表位位于MHC-II结合 ...

Determinants of HIV cell tropism & chemokine receptor usage The V3 loop of HIV-1 gp120 is a primary determinant of cell tropism and chemokine receptor usage, whereas the V1/V2 region is involved ...

The study shows that intact HIV and its viral envelope protein gp120 each cause macrophages, a type of white blood cell, to ...

This vaccine used a recombinant canarypox vaccine to prime immune responses plus protein subunits of the HIV surface protein (termed gp120) to boost immune responses. Further analysis of the data ...