通过线粒体转移，癌细胞不仅实现了对T细胞功能的精确抑制，还为其免疫逃逸增加了一道屏障。该研究进一步指出，这种机制与免疫治疗效果不佳密切相关，尤其是在携带大量mtDNA突变的患者中，免疫检查点抑制剂的疗效显著降低。

Lung cancer treatment and outcomes are profoundly influenced by the tumor microenvironment (TME), particularly in resectable ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

Immune cells in the bone marrow microenvironment of AML patients are key in distinguishing a response to immunotherapy.

Surrounding these epithelial cells is a microenvironment of supporting cells including stromal cells, such as lung fibroblasts, and tissue resident and transient circulating immune cells.

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

For more information, refer to the full study in Nature Communications.

Dr. Won Jin Ho presented a talk as part of the Immunology Neighborhood Seminar on “Overcoming the tumor immune ...