lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is activated by reduced local oxygen concentrations at the tumor site.

A new approach that used CRISPR to engineer adipocytes and implant them in mice models of cancer reduced cancer progression.

The article notes the results of the research done on mice, which were successfully administered nanorobotic agents into colorectal tumors. “The drug’s propelling force was enough to travel ...

Pancreatic cancer has the worst survival rates among all solid tumor types, and its incidence is increasing. Hypoxic conditions that arise from an imbalance between increased oxygen consumption and an ...

Therefore, hypoxia is generally associated with more aggressive cancers and poor patient outcomes, as it drives changes that ...

Tumor growth often outpaces the growth of its blood supply, leaving portions of the tumor in a state of oxygen deprivation known as hypoxia. While hypoxia is typically considered harmful to cells, it ...

Conversely, stabilization of HIF1α by knocking out a negative regulator of HIF1α increased IFN-γ under hypoxic conditions. With regard to defense against cancer, the researchers found that ...

During cancer, hypoxia-driven inflammation and inflammatory hypoxia can occur simultaneously. PKA-dependent HIF- 1α stabilization may have an impact in many of these disease processes and could ...

Reply to: Concerns on Potential Risk of Roxadustat in Promoting Tumor Progression: Double-Edged Sword of Hypoxia-Inducible Factor-1α Activation The following represents disclosure information provided ...

Vein-first versus artery-first ligation during lobectomy for NSCLC was linked to incremental change in circulating tumor cells and better survival outcomes. Early cancer detection and survival ...