lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is activated by reduced local oxygen concentrations at the tumor site.

When they compared the genes in the hypoxia-response signature of normal cells to that of different cancer cells, they found that they were able to classify different tumors by their hypoxia response.

Tumor growth often outpaces the growth of its blood supply, leaving portions of the tumor in a state of oxygen deprivation known as hypoxia. While hypoxia is typically considered harmful to cells, it ...

I n the complex landscape of cancer, tumors create their own microenvironment, often marked by low oxygen levels, a condition ...

Hypoxia, a condition characterized by reduced oxygen availability, has been widely studied for its potential therapeutic ...

However, for both TACE and TAE the resulting hypoxia will be a potent stimulator of angiogenesis, so that embolization might inadvertently promote tumor growth by rending the tumor hypoxic.

A new approach that used CRISPR to engineer adipocytes and implant them in mice models of cancer reduced cancer progression.

Conversely, stabilization of HIF1α by knocking out a negative regulator of HIF1α increased IFN-γ under hypoxic conditions. With regard to defense against cancer, the researchers found that ...

Pancreatic cancer has the worst survival rates among all solid tumor types, and its incidence is increasing. Hypoxic conditions that arise from an imbalance between increased oxygen consumption and an ...

Vein-first versus artery-first ligation during lobectomy for NSCLC was linked to incremental change in circulating tumor cells and better survival outcomes. Early cancer detection and survival ...