When the NFL season began, few would have bet the Cardinals (7-9) would enter Week 18 of the season with a better record than the 49ers (6-10). Expected to be the top seed in the NFC playoffs ...

Samuel has been a versatile piece for the 49ers since his arrival in 2019 as a second-round pick. In 81 games for San Francisco, he's tallied 5,935 scrimmage yards and has been a pivotal for the 49ers ...

The 49ers granted Samuel and his agent permission to seek a trade once this latest request came a month ago, when Samuel, 29, ...

For coach Jonathan Gannon and QB Kyler Murray, ending the season with a win will give Arizona a confidence boost heading into the offseason.

TV: FOX. Radio: 98.7 FM. Last time they played: The 49ers made easy work of the Cardinals in a 45-29 win last December. That defeat is the most points the Cardinals have allowed in a game since 2016.

The Arizona Cardinals will host the San Francisco 49ers at State Farm Stadium in Glendale, Arizona, on Sunday, January 5, at 1:25 p.m. PT. The Cardinals are currently favored by 4.5 points.

Stream the NFL on Fubo (try for free) and find the best ticket deals on StubHub. Q2 5:43 49ers 10, Cardinals 10 Josh Dobbs, starting for the banged-up Brock Purdy with the 49ers out of the playoff ...

D.J. Reed's path to free agency started with the San Francisco 49ers, who drafted him in the fifth round of the 2018 NFL ...

James Conner will not play in the Arizona Cardinals’ season finale against the San Francisco 49ers. He was placed on injured reserve earlier this week, ending his season. Several other Cardinals ...

The San Francisco 49ers are preparing for their Week 18 contest against the Arizona Cardinals on Sunday at State Farm Stadium in Glendale, Arizona. Several key players were absent from the second ...

Following a narrow 40-34 home loss to the Detroit Lions on "Monday Night Football," the 6-10 49ers conclude the season against the 7-9 Arizona Cardinals on Sunday at State Farm Stadium.