Chaperones are proteins that assist in protein folding and multi-protein complex assembly co-translationally or post-translationally. Generally, a single chaperone has multiple client proteins.

Those aggregates can have a dual role, on one hand sequestering the toxic protein, but on the other, acting as a hub to incorporate several proteins. While molecular chaperones are the first line of ...

Protein quantification is essential in a great variety of biochemical assays, yet the inherent systematic errors associated with the concentration determination of intrinsically disordered proteins ...

Among many of the viral offensive strategies, HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in the host-pathogen interaction and thus have significant ...

Combined with previous studies showing the dependence of rG4 structure on stress and the extreme power of rG4s at oligomerizing proteins, we propose a model of neurodegeneration in which chronic rG4 ...

This depends on the type of enzyme. The enzyme pepsin breaks down proteins in the acidic conditions of the stomach. Pepsin has an optimum of pH 2.5 and a working range of between pH 1-4.