Here, we experimentally examined diet-microbe- host interactions through a complex systems framework, centered on dietary oxalate. Using multiple, independent molecular, animal, and in vitro ...

Detecting danger is key to the survival and success of all species. Animal nervous and immune systems cooperate to optimize danger detection. Preceding studies have highlighted the benefits of ...

Formyl-methionyl-leucyl-phenylalanine or fMLF (F3506), DMSO, and Pertussis toxin (PT, P7208) were purchased from Sigma-Aldrich. Human recombinant CXCL8 (CHM349), CXCL1 or GROα (CHM329) and GM-CSF (CYT ...

In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is activated and complement is regulated, wrote, “In the study of biological processes, the accumulation of ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...