Using a liver-specific Plectin knockout mouse model, the authors showed solid evidence that PLECTIN is critical for hepatocarcinogenesis, since inhibition of PLECTIN suppressed tumor formation in ...

近期，韩国首尔大学Jung Weon Lee团队与韩国车医科大学（CHA）Young-Ger Suh团队联合发表了一项研究成果。他们揭示了，一种在肝 细胞癌 （HCC）组织中高度表达的跨膜蛋白TM4SF5，通过触发NK细胞刺激性配体SLAMF7的降解 ...

Macrophages exist in most tissues of the body, where they perform various functions at the same time equilibrating with other cells to maintain immune responses in numerous diseases including cancer.

2 Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China 3 State Key Laboratory of Liver Research, Li Ka Shing Faculty of Medicine, University of ...

As a metabolic center, the liver prevents inappropriate immune responses to abundant dietary antigens within the liver that could result in liver injury. This self-preservation mechanism can however ...

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States Department of Molecular Biology and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital ...

Target validation is the process by which the predicted molecular target – for example protein or nucleic acid – of a small molecule is verified. Target validation can include: determining the ...

This reduction in OATP8 expression occurs early in hepatocarcinogenesis, prior to the development of the vascular changes typical of overt HCC. The detection of HBP hypointense nodules without ...

Objective Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with limited treatment options. Cabozantinib, an orally bioavailable multikinase inhibitor is now approved by ...