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血液肿瘤靶点:ROR1 是受体酪氨酸激酶
急性髓系白血病(AML):约 35% 的 AML 患者细胞中表达 ROR1,在 THP1、MV4 - 11 和 NB4 等 AML 细胞系中也有表达,提示 ROR1 疗法可能对 AML 有效26。 针对 ROR1 的治疗策略 单克隆抗体:如 cirmtuzumab(UC - 961)、抗 ROR1 的 mAbs 等,可通过与 ROR1 结合诱导细胞毒性,抑制其 ...
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