Mutations in TP53 gene disrupt this link and promote EMT. Transcription factors Zeb1 and Zeb2 are regulated not only by the miR-200 family members but also by other miRs. For example, it was shown ...

p53 dysfunction and mTOR pathway hyperactivation are hallmarks of human cancer. The balance between response to stresses or commitment to ... The tumor suppressor p53, a stress-induced transcription ...

Background While p53 mutations occur early in Barrett’s oesophagus (BE ... RF is supported by NIH grants 5R01DK128195 and 5P30CA013696 (Cancer Center Support Grant). KN-O received support from NIH R01 ...

inactivation of p53-induced apoptosis, impairment of DNA repair, enhancement of the expression of proteins involved in inflammation, and modulation of the expression of microRNAs and genes ...

Jan. 28, 2025 — A data analysis from a randomized clinical trial for stage 3 colon cancer patients found that patients with evidence of residual cancer in their blood after surgery to remove the ...

and also in cancer development. Besides describing the basic mechanisms governing programmed cell death, a large part of this review is dedicated to previous studies that were focused on screening ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

For decades, scientists have tried to stop cancer by disabling the mutated proteins that are found in tumors. But many cancers manage to overcome this and continue growing. Now, scientists think they ...

5-Fluorouracil and other p53-activating cytotoxic drugs promote ... Moreover, it might be possible to combine agents that induce direct cancer-cell-specific and immunostimulatory effects for ...

However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

Cancer Prevention Research publishes articles that focus on cancer prevention, preclinical, clinical, and translational research, with special attention given to molecular discoveries and an emphasis ...

Properly positioning yourself? Venus’ entrance to Aries is good for your career! Superiors are taking note of the precedent you set. You make business look easy, and others want to follow your ...