The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

Mutant p53 and Mdm2 inhibit only a subset of wild type p53 targets in a manner independent of gene occupancy. The C-terminal 19 amino acids of wild type p53 suppress the p53 response at sublethal ...

Mutations in TP53 gene disrupt this link and promote EMT. Transcription factors Zeb1 and Zeb2 are regulated not only by the miR-200 family members but also by other miRs. For example, it was shown ...

Investigation of the association of CTRB2 exon 6 deletion with time to progression and overall survival in pancreatic ductal adenocarcinoma. This is an ASCO Meeting Abstract from the 2025 ASCO ...

p53 dysfunction and mTOR pathway hyperactivation are hallmarks of human cancer. The balance between response to stresses or commitment to ... The tumor suppressor p53, a stress-induced transcription ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical ...

Background While p53 mutations occur early in Barrett’s oesophagus (BE ... RF is supported by NIH grants 5R01DK128195 and 5P30CA013696 (Cancer Center Support Grant). KN-O received support from NIH R01 ...

MDM2, on the other hand, is one of the most frequently studied oncogenes and is an excellent target for cancer therapy, based on its p53-dependent ... published in the Genes & Diseases journal ...

inactivation of p53-induced apoptosis, impairment of DNA repair, enhancement of the expression of proteins involved in inflammation, and modulation of the expression of microRNAs and genes ...

Jan. 28, 2025 — A data analysis from a randomized clinical trial for stage 3 colon cancer patients found that patients with evidence of residual cancer in their blood after surgery to remove the ...

In a nutshell A common desert plant called Artemisia herba-alba contains compounds that can effectively kill colorectal ...