Aa Aa Aa It seems nearly impossible for a normal cell to become a cancer cell unless it inactivates the p53 network. Our current understanding of this network has come from diverse lines of ...

The fragile structure of p53 gene reveals why this crucial cancer defense is so easily compromised, shedding light on the genetic Achilles' heel of many tumors. In a recent perspective published ...

Investigation of the association of CTRB2 exon 6 deletion with time to progression and overall survival in pancreatic ductal adenocarcinoma. This is an ASCO Meeting Abstract from the 2025 ASCO ...

This form of cancer arises from Barrett's esophagus ... this loss appears to protect cells from losing another crucial gene, p53, which is a tumor suppressor known as the "guardian of the ...

Mutations in the p53 gene (TP53) are often associated with aggressive tumor ... approaches to understand p53 action and the immediate effects of p53 loss in sporadic cancer progression. p53 ...

The groups interested in studying p53 next wanted to investigate its interactions with T antigen. Scientists made these findings as the theory of oncogenes, the idea that mutated host growth-promoting ...

Perhaps the earliest and arguably the most successful example of studying differential gene expression in cancer was the discovery of the p53 tumour-suppressor protein in the late 1970s.

A kidney cancer cell nucleus is studded with aberrant nuclear speckles (orange). Normal healthy cells tend to have the speckles clustered toward the middle. Image credit: Kate Alexander (Cold Spring ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature. 2010;468(7323):572-5. 5. Morris JPt, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS ...