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A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct ...

In many cellular settings, the first regulatory process (see figure, step 1) involves the de-repression of the mTOR Ser/Thr kinase, which inhibits autophagy by phosphorylating autophagy protein-13 ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz investigated ...

Glucose-6-phosphate dehydrogenase (G6PD) is the only rate-limiting enzyme in the pentose phosphate pathway (PPP). Rapidly proliferating cells require metabolites from PPP to synthesize ribonucleotides ...

Jack E Dixon as a postdoctoral fellow from 2014 to 2020. During that time his research was focused on the role of DYRK2 as a kinase phosphorylating and regulating the 26S proteasome. As a post ...

Soybean germplasm is highly diverse and natural variations exist for salt tolerance. Recent omics approaches such as transcriptomics, quantitate traits loci (QTL), and genome-wide association studies ...

This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...

The reason for this lies in the cyclins' cooperation with a kinase. Kinases are responsible for phosphorylating amino acids in substrates – a key process for cell division. Another important ...