Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

escalation of the polyol and other collateral glycolysis pathways, 4) impaired hexokinase (HK) activity and glucose utilization in the glycolytic pathway, and 5) further escalation of the polyol ...