Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

PARP then modifies GAPDH, thereby reducing its activity. Finally, decreased GAPDH activity activates the polyol pathway, increases intracellular AGE formation, activates PKC and subsequently NFκB ...

The wide range of performance properties of polyurethane foams makes them essential in many consumer goods. Thus, there is ...

Consecration and 10 steps to cleansing. They do dovetail with our responsibilities. What is required of a priest and how does the priesthood parallel with those who are Christians? Can you draw a ...

Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes. Microvascular endothelial cells are thought to be the major targets of hyperglycemic injury. In ...

It is to be explored how to avoid the interference of other mechanisms in the demonstration of cell ferroptosis. In addition, the specific molecular mechanisms and pathways of ferroptosis in disease ...

Artificial sweeteners are everywhere, even in foods you may not consider sweet. Here are five expert tips on how to cut or ...

Department of Energy Science and Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India ...

Hope is not passive wishing but an active, dynamic process. According to Hope Theory, hope involves two components: agency and pathways. Agency is the belief in one’s capability to act ...

To the cell biologist, however, 'endothelial cell dysfunction' may represent an alteration of an extensive gene program and changes in a host of signaling pathways and secreted factors.