Researchers at the University of Liège (Belgium) have uncovered a previously unknown mechanism that regulates the immune ...

T lymphocyte activation is a pivotal step of the adaptive immune response. It requires the recognition by T-cell receptors (TCR) of peptides presented in the context of major histocompatibility ...

This review focus on updating and integrating findings on T lymphocyte signaling generated using global phosphoproteomics approaches, drawing attention on the biological relevance of the obtained data ...

In a mid-stage study, the candidate itolizumab achieved 23.3% clinical remission rate at 12 weeks, numerically better than ...

Atypical lymphocytes that survive genetic damage ... Separation of atypical lymphoid proliferation from reactive hyperplasia and malignant lymphomas is shown in Figure 6. However, it should ...

Unlike other cells, activated lymphocytes expand their pyrimidine pool by approximately eightfold during proliferation; purine pools are increased only twofold. To meet this demand, lymphocytes must ...

Fcα/μR is constitutively expressed on the majority of B lymphocytes and macrophages. Cross-linking Fcα/μR expressed on a pro-B cell line Ba/F3 transfectant with soluble IgM or IgM-coated ...

Although only transiently expressed, the pre-BCR marks an important checkpoint in B-cell development and regulates diverse processes, such as proliferation, allelic exclusion of the second heavy ...

Teriflunomide: Inhibits mitochondrial enzyme dihydroorotate hydrogenase to decrease lymphocyte proliferation. TEMSO Phase III trial with positive results, multiple other Phase III trials underway.

Atopic dermatitis is a chronic inflammatory skin disease affecting a growing number of people worldwide. Marked by persistent ...