The controversy over Sirtris drugs reached a tipping point in January with a publication by Pfizer researchers led by Kay Ahn showing that resveratrol activates SIRT1 only when linked to a ...

We have been interested in the physiologic role of Sirt1 in skeletal muscles. We have recently unraveled a mechanism of transcription regulation of the Sirt1 gene by the EGR1 (early growth response ...