Most solid human tumours contain regions of acute and chronic hypoxia or anoxia that can herald a negative clinical prognosis for the cancer patient owing to local resistance and systemic metastases.

lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is activated by reduced local oxygen concentrations at the tumor site.

Therefore, hypoxia is generally associated with more aggressive cancers and poor patient outcomes, as it drives changes that ...

Tumor growth often outpaces the growth of its blood supply, leaving portions of the tumor in a state of oxygen deprivation known as hypoxia. While hypoxia is typically considered harmful to cells, it ...

Conversely, stabilization of HIF1α by knocking out a negative regulator of HIF1α increased IFN-γ under hypoxic conditions. With regard to defense against cancer, the researchers found that ...

During cancer, hypoxia-driven inflammation and inflammatory hypoxia can occur simultaneously. PKA-dependent HIF- 1α stabilization may have an impact in many of these disease processes and could ...

Pancreatic cancer has the worst survival rates among all solid tumor types, and its incidence is increasing. Hypoxic conditions that arise from an imbalance between increased oxygen consumption and an ...

Reply to: Concerns on Potential Risk of Roxadustat in Promoting Tumor Progression: Double-Edged Sword of Hypoxia-Inducible Factor-1α Activation The following represents disclosure information provided ...