Ubiquitin is an intracellular signalling molecule that is conjugated to various proteins. Ubiquitin conjugation to itself yields Lys- or Met-conjugated chains, thus expanding its repertoire of ...

A superfamily of approximately 100 ubiquitin-specific proteases, called deubiquitylating enzymes, deubiquitinases or DUBs, remove ubiquitin from target proteins, disassemble polymeric ubiquitin ...

FSTL1 directly binds to pyruvate kinase M2 (PKM2), inhibits ubiquitin-mediated degradation, enhances the stability of cytoplasmic PKM2 and promotes PKM2 phosphorylation and nuclear translocation in ...

Glucose-6-phosphate dehydrogenase (G6PD) is the only rate-limiting enzyme in the pentose phosphate pathway (PPP). Rapidly proliferating cells require metabolites from PPP to synthesize ribonucleotides ...

In more than one hundred DUBs, ubiquitin-specific proteases (USPs) subfamily is the largest and the most widely studied member. USP13, as an important deubiquitinase member belongs to USPs subfamilies ...

Background Schaaf-Yang syndrome (SYS) is caused by truncating mutations in MAGEL2, mapping to the Prader-Willi region (15q11-q13), with an observed phenotype partially overlapping that of Prader-Willi ...