This valuable study uses zebrafish as a model to reveal a role for the cell cycle protein kinase CDK2 as a negative regulator of type I interferon signaling. The evidence supporting the authors' ...

Moreover, the E3 ubiquitin ligase, Dtx4, is implicated in the process by which CDK2 increases the K48-linked ubiquitination of TBK1. This paper presents intriguing findings on the function of CDK2 in ...

Ubiquitin is an intracellular signalling molecule that is conjugated to various proteins. Ubiquitin conjugation to itself yields Lys- or Met-conjugated chains, thus expanding its repertoire of ...

The Department of Biochemistry and Molecular Pharmacology at NYU Langone Health has a rich and distinguished history and maintains active research programs in epigenetics, genome integrity, protein ...

Hartmut received his PhD from the University of Vienna for his work on ubiquitination and the cell cycle carried out in the group of Jan-Michael Peters. In his postdoctoral work in the laboratory of ...

【导读】蛋白质O-GlcNAcylation是一种与细胞代谢可塑性相关的翻译后修饰。在许多癌症中，包括妇女常见的恶性肿瘤子宫内膜癌（EC）中都观察到了异常的O-GlcNAcylation。然而，对子宫内膜癌中失调的O-GlcNAcylation平衡的 ...

The USP9X inhibitors WP1130 and EOAI3402143 were used to treat the DSS-induced colitis. Ubiquitination label-free quantitative proteomic analysis was performed to identify protein peptides that may ...

【导读】三阴性乳腺癌（TNBC）是一种预后较差的乳腺癌亚型。天然化合物扁蒴藤素具有良好的抗肿瘤作用。1月15日，南方医科大学与香港浸会大学研究人员合作共同在期刊《Advanced Science》上发表了题为“扁蒴藤素 Promotes Ubiquitination of HSPA8 and Activates the VAV1/ERK Pathway to Suppress TNBC Proli ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

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Department of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States ...