Background: In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG). Recent evidence strongly suggests ...

Abstract: Acetazolamide (AZA) reduces the water permeability of aquaporin-4, the predominant water channel in the brain. We determined the structure of aquaporin-4 in the presence of AZA using ...

Aquaporins (AQPs) are transmembrane proteins that play a vital role in the rapid transport ... inhibiting the synthesis of TTF-1 increased the survival rate of animals with acute water ...

Recently, we reported some distinct characteristics between seropositive anti-aquaporin-4 (anti-AQP4) patients and seropositive antimyelin oligodendrocyte glycoprotein (anti-MOG) patients with NMOSD, ...

Aston Institute for Membrane Excellence (AIME) has received a £500,000 grant from the Wolfson Foundation to purchase an ultrafast confocal spinning disc microscope. This instrument will accelerate ...

Aston Institute for Membrane Excellence (AIME) has been awarded a £500,000 grant from the Wolfson Foundation to acquire an ultrafast spinning disc confocal microscope, enhancing research into ...

Objective To establish if myelitis-associated chronic pain in NMOSD is related to the craniocaudal location of spinal cord lesions. Method (1) Retrospective cohort of 76 aquaporin 4-antibody (AQP4-Ab) ...

The following is a summary of “Brain tissue integrity in neuromyelitis optica spectrum disorder through T1-w/T2-w ratio, MTR ...

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Immunotherapy treatment was effective at reducing attack recurrence in patients with NMOSD but was less effective for MOGAD, a study found.

Lastly, by using actual data from a previously published clinical study that enrolled patients with anti-aquaporin-4 antibody-positive NMOSD (8), the obtained ARR and the 95% CI are compared between ...