Human cancer cell lines MCF7 (RRID: CVCL_0031), MDA-MB-231 (RRID: CVCL_0062), and non-malignant MRC5 (RRID: CVCL_0440) cells were obtained from the American Type Culture Collection (ATCC). All cells ...

Ltd. (Wuhan, China). The MDA-MB-231 cells were treated with 20 μM PB or DMSO for 24 h, and then collected. Cells were lysed using RIPA lysis buffer containing PMSF. Anti-TRIB3 antibody (batch no.

精准医学的发展依赖于对患者基因组及其相关脆弱性的深入理解。合成致死是一种精准治疗癌症的策略，即同时敲除两个单独非必需基因会导致细胞活力丧失。过去 15 年，合成致死癌症靶点发现方法取得了临床成果，如 PARP 抑制剂的成功应用，同时也推动了 WRN、USP14 等新一代治疗靶点进入临床。随着 CRISPR 技术和基因组分析技术的发展，结合大型数据集，为在不同遗传背景下识别更多合成致死靶点提供了契机 ...

Solid lines represent sigmoidal best-fit curves. (B-E) Heatmaps of single-cell traces for CDK4/6 (left) and CDK2 (middle) activities, and Cdt1-degron intensity (right) in various conditions: ...

Cell culture is a key technique in scientific research. It lets scientists grow and study cells outside their natural ...

The Under-oil Open Microfluidic System enhances tumor cell-ECM interaction studies, improving anti-metastatic drug testing for triple-negative breast cancer.

(5) Validation with Multiple Cell Lines: The research utilized multiple HR+/HER2- breast cancer cell lines (such as MCF-7, T47D, CAMA-1) and triple-negative breast cancer cell lines (such as ...

This page has been specifically created for those customers who purchase MDA-distributed products and may be occupationally exposed to potentially hazardous substances. These concerns are applicable ...