BoNTs are complex, multifunctional protein neurotoxins. While the mechanism of action is “superficially simple”, many factors are still not fully understood, explains Chaddock. “The toxins ...

The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

Neurotoxins like Botox, Dysport, Xeomin, and Jeuveau are injectable medications derived from botulinum toxin, a naturally occurring substance. Once upon a time, conversations about Botox and ...

The mechanism of action underlying ketamine’s rapid antidepressant effects in patients with depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD), including ...

This review draws attention to new findings about the mechanism of action of botulinum toxin and briefly reviews some of its most frequent ... Three dimensional structure shows that the neurotoxins ...

Nevertheless, investigations are needed to better understand the potential mechanisms to address these neurotoxicants and improve approaches ... We also welcome any putative new innovative treatment ...

Each year, over two million people fall victim to snakebites, resulting in more than 100,000 fatalities and 300,000 severe ...

Yet the precise mechanisms of action for DBS remain uncertain. Here we give an up-to-date overview of the principles of DBS, its neural mechanisms and its potential future applications.

Jammu: Amid growing concern over the mysterious death of 14 persons in a remote village in Jammu and Kashmir over the past one month, health experts on Tuesday said certain neurotoxins have been found ...

Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K. Protein kinase R-like ...