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A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct ...

In many cellular settings, the first regulatory process (see figure, step 1) involves the de-repression of the mTOR Ser/Thr kinase, which inhibits autophagy by phosphorylating autophagy protein-13 ...

Jack E Dixon as a postdoctoral fellow from 2014 to 2020. During that time his research was focused on the role of DYRK2 as a kinase phosphorylating and regulating the 26S proteasome. As a post ...

Glucose-6-phosphate dehydrogenase (G6PD) is the only rate-limiting enzyme in the pentose phosphate pathway (PPP). Rapidly proliferating cells require metabolites from PPP to synthesize ribonucleotides ...

Soybean germplasm is highly diverse and natural variations exist for salt tolerance. Recent omics approaches such as transcriptomics, quantitate traits loci (QTL), and genome-wide association studies ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical ...

The reason for this lies in the cyclins' cooperation with a kinase. Kinases are responsible for phosphorylating amino acids in substrates – a key process for cell division. Another important ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...