The proteasome-part of the internal cellular machinery-breaks down specific cellular proteins. Ubiquitin is a protein that attaches to other proteins to earmark them for degradation by helping the ...

mechanisms of an assembly-coupled degradation via an oncorpotein and assembly chaperone, Gankyrin in cancers, and (iii) signaling pathways for active disassembly of the proteasome via the chaperones ...

Protein folding: Ensured by molecular chaperones to maintain functionality. ・Degradation: Damaged proteins are broken down via the ubiquitin-proteasome system or lysosomes. ・Aggregate ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

Booster Therapeutics has announced its inception, backed by a $15m investment, to develop a new class of proteasome activator ...