In contrast, oversized cells that undergo compensatory growth slowdown exhibit a superlinear increase in proteasome-mediated protein degradation, with accelerated protein turnover per unit mass, ...

Misfolded proteins are the main common feature of neurodegenerative diseases, thereby, normal proteostasis is an important mechanism to regulate the neural survival and the central nervous system ...

PROteolysis TArgeting Chimeras (PROTACs) are small molecules that induce target protein degradation via the ubiquitin-proteasome system. PROTACs recruit the target protein and E3 ligase; a critical ...

The proteasome is a large protein complex in the cytoplasm of eukaryotic and archaeal cells responsible for proteolysis of proteins that have one or more poly-ubiquitin post-translational ...

The proteasome-part of the internal cellular machinery-breaks down specific cellular proteins. Ubiquitin is a protein that attaches to other proteins to earmark them for degradation by helping the ...

People with diabetes should eat as much protein as people who don't have diabetes. In a healthy diet, roughly 10% to 35% of your daily calories should come from protein. Protein itself does not have ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

One main macronutrient that should have a prominent place in every person’s diet is protein. Protein plays a crucial role in processes like tissue repair, exercise recovery, muscle building ...

Nobel Laureate Aaron Ciechanover emphasizes the importance of democracy in science for progress and innovation.

Milk is high in protein, with 1 gram per ounce and 8 grams in a cup of cow's milk. People need protein to build and repair healthy tissue, help kids and teens grow, control hunger, and more. Besides ...