In this new study, the researchers found a genetic variant that results in differences in tubulin protein production between ...

Microtubules are the largest type of filament, with a diameter of about 25 nanometers (nm), and they are composed of a protein called tubulin. Actin filaments are the smallest type, with a ...

The taxanes exert their cytotoxic effect by binding tubulin, stabilizing the microtubule and inhibiting its disassembly, ultimately leading to cell death by apoptosis. Although there is no maximum ...

You have full access to this article via your institution. There are several methods for removing MAPs from MTP to produce purified tubulin: using DEAE-Sephadex or phosphocellulose chromatography ...

Proteins containing disordered domains perform many important cellular functions. My lab currently has two main projects, one to dissect the role of tubulin's C-terminal tail in microtubule structure ...

Pancreatic cancer is a challenge due to its poor prognosis and high mortality rate, highlighting the need for new therapeutic approaches. Previous findings have shown that AUS-001 inhibits β-tubulin ...

A phase 1/2 study evaluating the safety and efficacy of autologous TAC T cells in subjects with claudin 18.2+ advanced solid tumors. This is an ASCO Meeting Abstract from the 2025 ASCO ...