Ubiquitin is an intracellular signalling molecule that is conjugated to various proteins. Ubiquitin conjugation to itself yields Lys- or Met-conjugated chains, thus expanding its repertoire of ...

(F) Mass spectrometry analysis of a peptide derived from ubiquitinated TBK1-Myc. (G and H) TBK1 ubiquitination assays in EPC cells transfected with indicated plasmids for 18 h, followed by MG132 ...

This valuable study uses zebrafish as a model to reveal a role for the cell cycle protein kinase CDK2 as a negative regulator of type I interferon signaling. The evidence supporting the authors' ...

Glucose-6-phosphate dehydrogenase (G6PD) is the only rate-limiting enzyme in the pentose phosphate pathway (PPP). Rapidly proliferating cells require metabolites from PPP to synthesize ribonucleotides ...

FSTL1 directly binds to pyruvate kinase M2 (PKM2), inhibits ubiquitin-mediated degradation, enhances the stability of cytoplasmic PKM2 and promotes PKM2 phosphorylation and nuclear translocation in ...

In more than one hundred DUBs, ubiquitin-specific proteases (USPs) subfamily is the largest and the most widely studied member. USP13, as an important deubiquitinase member belongs to USPs subfamilies ...

Specifically, hSPAR fulfills its functions by two coordinate pathways: On one hand, hSPAR stabilizes the protein level of P27KIP1 in the cytoplasm by blocking TRIM21-mediated ubiquitin-proteasome ...

Background Schaaf-Yang syndrome (SYS) is caused by truncating mutations in MAGEL2, mapping to the Prader-Willi region (15q11-q13), with an observed phenotype partially overlapping that of Prader-Willi ...