Short-chain fatty acids (SCFAs) like propionate and butyrate are critical byproducts of dietary fiber digestion. These molecules do more than fuel the body—they directly influence gene expression and ...

Mass spectrometry analysis with isotopically labeled NaPr further validated the direct incorporation of SCFAs as propionyl-CoA and butyryl-CoA, facilitating histone acylation. Notably, histone ...

The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead ...

Correspondence to Dr Ailsa Hart, IBD Unit, St Mark's Hospital and Imperial College London, Watford Road, London HA13UJ, UK; ailsa.hart{at}nhs.net Over the last 10–15 years, our understanding of the ...

Introduction: Ovarian cancer has been difficult to cure due to acquired or intrinsic resistance and therefore, newer or more effective drugs/approaches are needed for a successful treatment in the ...

Due to the influx of illicitly synthesized fentanyl analogs, (19,20) detection and subsequent control of these substances has also become increasingly difficult. Law enforcement and emergency ...

Correspondence to Professor Bernd Schnabl, Department of Medicine, University of California, San Diego, CA 92093, USA; beschnabl{at}ucsd.edu The spectrum of non-alcoholic fatty liver disease (NAFLD) ...