The best-characterized targets for PADs are arginine residues in histone tails, which, when citrullinated, alter chromatin structure and gene expression. Methodological advances have allowed for the ...
Antibodies to cyclic citrullinated peptide (CCP) have high specificity, but low sensitivity for early RA, and CCP is not expressed in the synovial membranes. However, data from a new study suggest ...
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