Orthopaedic disorders are lifechanging ailments that touch every one of us, whether personally, or through the challenging experiences of family members or friends. The Orthopaedic Research Society ...

Osteoporosis is a disease in which bone resorbs faster than it is formed, gradually weakening its structure over time and ...

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...

This work presents important findings regarding the interaction of the monkeypox virus (MPXV) attachment H3 protein with the cellular receptor heparan sulfate and the use of this information to ...

1 Department of Targeting Therapy and Immunology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China 2 Division of Thoracic Tumor Multimodality Treatment, Cancer Center, ...

Bone tissue is a complex structure, consisting of mineralized collagen fibers and a variety of non-collagenous proteins, including proteoglycans such as biglycan and decorin. These proteoglycans ...

A recent study has uncovered the essential roles of two proteoglycans, biglycan and decorin, in maintaining bone mass, water retention, and bulk/in situ mechanical competence. Through the use of ...

Table 2. Preclinical studies reporting enhancement of intratumoral OV distribution by inhibition of ECM synthesis. Furthermore, the ECM normalization effects of decorin expression offer opportunities ...

Smooth muscle cells (SMCs) of the proximal thoracic aorta are derived from second heart field (SHF) and cardiac neural crest lineages. Recent studies, both in vitro and in vivo, have implied relevance ...