Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is predominantly caused by desmosomal genetic variants, and clinical hallmarks include arrhythmias and systolic dysfunction. We aimed ...

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Discussion: Alterations of the desmosomal plaque ultrastructure are closely related to loss of adhesion and regulated differently by signaling pathways involved in pemphigus pathogenesis. This insight ...

Furthermore, an altered outside-in-signaling caused by antibodies has been thought to cooperate in damaging the desmosomal integrity (46). Furthermore, it was reported that the secretion of cytokines ...

The term dilated cardiomyopathy (DCM) refers to a spectrum of heterogeneous myocardial disorders that are characterized by ventricular dilation and depressed myocardial performance in the absence of ...

Collective cell migration is defined as the coordinated movement of multiple cells that retain cell–cell contacts while coordinating their actin dynamics and intracellular signalling. Because ...

Pemphigus is an autoimmune bullous disease, in which autoantibodies react with the cell–cell adhesion structures, desmosomes, causing blisters and erosions on the oral mucosa and skin. Pemphigus ...

Pemphigus is a rare autoimmune blistering disease involving the skin and mucous epithelia. It is clinically characterized by flaccid blisters and erosions (Figure 1) and, if left untreated, could ...