Translation of human pluripotent stem cells into cell therapies will require the development of standardized tests for product consistency, stability, tumorigenicity, toxicity and immunogenicity.
The overexpression of four specific transcription factors allows for reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), which can give rise to all cell types of the adult body ...
Other iPSC-based models affecting neural crest lineages include Schwann cell and melanocyte-related disorders, including our effort to model human melanoma in pluripotent stem cells. Modeling herpes ...
The main focus in the lab is on the biology and application of human embryonic stem (ES) and human induced pluripotent (iPS) cells. Pluripotent stem cells can provide a truly unlimited source for ...
Pluripotent stem cells are known for the need to grow as colonies in order to prevent differentiation. This adds complexity to the isolation/expansion of clonal populations following research ...
Our group examines the hereditary causes of growth and development using human pluripotent stem cells. We model rare diseases and develop evidence-based treatments for patients with delayed puberty.
Patient-derived induced pluripotent stem cell (iPSC) organoids have emerged as an innovative tool for disease modeling and drug evaluation. Growing evidence highlights the advantages of organoids ...