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How are induced pluripotent stem (iPS) cells different from embryonic stem (ES) cells? What can we use iPS cells for? ES cells were originally derived from the inner cell mass (ICM) or epiblast of ...

Translation of human pluripotent stem cells into cell therapies will require the development of standardized tests for product consistency, stability, tumorigenicity, toxicity and immunogenicity.

At the Third International Summit on Human Genome Editing, held in March 2023 at the Francis Crick Institute in London, ...

Induced pluripotent stem cells (iPSCs) are a hopeful alternative for analyzing antigen expression in vitro and developing novel cellular therapies. iPSCs have been derived from differentiated ...

In 2006, Kazutoshi Takahashi and Shinya Yamanaka made a revolutionary breakthrough when they reprogrammed terminally differentiated, lineage-restricted adult somatic cells into a pluripotent state via ...

Pluripotent stem cells are known for the need to grow as colonies in order to prevent differentiation. This adds complexity to the isolation/expansion of clonal populations following research ...

Patient-derived induced pluripotent stem cell (iPSC) organoids have emerged as an innovative tool for disease modeling and drug evaluation. Growing evidence highlights the advantages of organoids ...

Other iPSC-based models affecting neural crest lineages include Schwann cell and melanocyte-related disorders, including our effort to model human melanoma in pluripotent stem cells. Modeling herpes ...

Susan Kimber (left) is a Professor at the University of Manchester (UK), where for the past 15 years, she and her lab have been working on human pluripotent stem cells for tissue engineering ...