Joseph Arboleda-Velasquez of Harvard Medical School praised the results. “Ye’s group has now provided compelling evidence showing increased binding affinity of ApoE3 Christchurch for tau and its ...

Like a well-run city, healthy cells recycle their waste, breaking down and reusing damaged proteins. In the January 29 Nature, scientists led by Jeffrey Bode and Jacob Corn at the Swiss Federal ...

The U.S. Food and Drug Administration approved Eisai and Biogen’s application for IV maintenance dosing of lecanemab on January 27. Previously, the label called for biweekly IV dosing. The new ...

For each structural strain of tau fibrils, they identified amino acids without which the strain cannot form its signature ...

This transgenic model of tauopathy expresses MAPT with the P301S mutation, which is associated with autosomal-dominant disease in humans. The hTau.P301S model recapitulates several molecular, cellular ...

Could synucleinopathies start in the kidneys? In the January 23 Nature Neuroscience, scientists led by Zhentao Zhang at Wuhan University, China, report that, in people with Parkinson’s and Lewy body ...

The X contains more genes related to brain function than does any other chromosome. “The X chromosome may be a treasure trove of genes that influence cognition, and these could be therapeutic targets, ...

This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...