Discover the identification of vimentin IgG autoantibodies in a novel autoimmune meningoencephalomyelitis, highlighting unique clinical features and implications for diagnosis and treatment.

近日，首都医科大学宣武医院神经内科郝峻巍教授团队在《JAMA Neurology》发表了题为“Novel Meningoencephalomyelitis Associated with Vimentin IgG Autoantibodies”的研究论文。该研究使用高通量单细胞免疫组库技术，首次发现了脑脊液中存在靶向星形胶质细胞波形蛋白 ...

1月22日，首都医科大学宣武医院神经内科郝峻巍教授团队在JAMA Neurology发表研究论文，该研究利用高通量单细胞免疫组库技术，首次发现了脑脊液中存在靶向星形胶质细胞波形蛋白(Vimentin)自身抗体，并提出一种与该自身抗体相关的新型脑膜脑脊髓炎综合征。JAMA Neurology副主编国际著名神经免疫专家加州大学旧金山分校 ...

该研究首次阐明波形蛋白为一种新的神经系统自身免疫疾病靶标，并为一种新型脑膜脑脊髓炎提供了诊断标志物。这项发现为该疾病类型患者的早期诊断和免疫干预提供了依据，避免了患者因反复发作和残疾积累最终导致不良预后。另外，该研究展示了单细胞免疫组库分析在探索中枢神经系统疾病及神经自身抗体识别中的潜力，启发了未来神经系统自身免疫疾病新的诊断和治疗方向。

Antimicrobials, vaccinations, and anti-inflammatory drugs were associated with a reduced risk of dementia in a systematic review, while diabetes drugs, vitamins and supplements, and antipsychotics ...

The possible involvement of other cellular components in viral entry mechanisms remains unknown. Vimentin is expressed in human endothelial cells, binds to SARS-CoV-2-spike, and expedites SARS-CoV-2 ...

This valuable manuscript provides an interesting account documenting the role of resident CD56(br) NK cells in driving interaction with dendritic cells that attract CD8+ T cells to the pancreas cancer ...

The Cellular Imaging shared resource at Fred Hutch provides advanced light microscopy services for biomedical and translational research. Our expert staff provides a complete workflow, including ...

This important work provides another layer of regulatory mechanism for TGF-beta signaling activity. The evidence supports the involvement of microtubules as a reservoir of Smad2/3, however, additional ...