p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.

p38 mitogen-activated protein kinases (p38 MAPK) are a class of evolutionarily conserved serine/threonine mitogen-activated protein kinases (MAPKs; see Glossary) that link extracellular signals to the intracellular machinery to regulate a plethora of cellular processes.

This review outlines current understanding of p38 MAPK family members and their involvement in tumor development, as well as the strategies to treat cancer based on targeting p38.

Potent inhibitors of p38 MAPKs have been pursued as potential therapies for several disease indications due to their antiinflammatory properties, although none have been approved to date. Here, we provide a brief overview of p38 MAPKs, including their role in regulating myogenesis and their association with disease progression.

2005年1月1日 · One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this review, we highlight the...

p38 Mitogen Activated Protein Kinase (p38 MAPK) also known as Stress Activated Protein Kinase (SAPK) is recognised as a critical regulator of signal transduction mechanisms involved in interpretation and adaptation of cells to a variety of external signals like cytokines and cellular stresses like osmotic shock, lipopolysaccharide (LPS), UV ...

The p38 (MAPK) protein kinases affect a variety of intracellular responses, with well-recognized roles in inflammation, cell-cycle regulation, cell death, development, differentiation, senescence and tumorigenesis.

2020年3月11日 · The p38 MAPK pathway is well known for its role in transducing stress signals from the environment. Many key players and regulatory mechanisms of this signaling cascade have been described to some extent.

2010年8月1日 · The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to interpret a wide range of external signals and respond appropriately by generating a plethora of different biological effects.

2003年9月1日 · Four homologues/isoforms of p38 MAPK have been identified: p38α, p38β, p38γ and p38δ. Of these, p38α is the best characterized and perhaps the most physiologically relevant kinase involved in...