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2022年6月1日 · Learn about ALAD Porphyria, including symptoms, causes, and treatments. If you or a loved one is affected by this condition, visit NORD to find resources and Patients & Caregivers

The ALAD gene provides instructions for making an enzyme known as delta-aminolevulinate dehydratase. Learn about this gene and related health conditions.

ALAD Porphyria (ADP) is a very rare genetic metabolic disease characterized by almost complete deficiency of the enzyme delta-aminolevulinic acid (ALA) dehydratase. In ADP, the gene responsible is ALAD which produces the enzyme δ-aminolevulinic acid dehydratase.

2024年12月24日 · ALAD (Aminolevulinate Dehydratase) is a Protein Coding gene. Diseases associated with ALAD include Porphyria, Acute Hepatic and Porphyria Due To Ala Dehydratase Deficiency. Among its related pathways are Heme biosynthesis and Innate Immune System.

2025年1月4日 · The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins).

2025年1月4日 · The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity.

2001年7月1日 · The ALAD gene (chromosome 9q34) codes for delta-aminolevulinic acid dehydratase (ALAD) (E.C. 4.2.1.24). ALAD catalyzes the second step of heme synthesis and is polymorphic. The ALAD G177C polymorphism yields two codominant alleles, ALAD-1 and ALAD-2, and it has been implicated in susceptibility to l …

The ALAD gene encodes delta-aminolevulinate dehydratase, also known as porphobilinogen synthase (PBGS; EC 4.2.1.24), a cytosolic enzyme that catalyzes the second step in the porphyrin and heme biosynthetic pathway.

2024年12月10日 · The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins).