A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.

BRCA2 and BRCA2 (/ ˌ b r æ k ə ˈ t uː / [5]) are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2 ; currently BRCA2, DNA repair associated ) are maintained by the HUGO Gene Nomenclature Committee .

乳腺癌二号基因（brca2）是一种导致乳腺癌的蛋白质基因，在人体中表达为编码brca2的基因其与brca1一起构成了乳腺癌的主要致病基因。 BRCA1与BRCA2是两种不相关的蛋白质 [ 6 ] ，但通常都在 乳房 与其他细胞组织中出现。

The BRCA2 gene provides instructions for making a protein that acts as a tumor suppressor. Tumor suppressor proteins help prevent cells from growing and dividing too rapidly or in an uncontrolled way. The BRCA2 protein is involved in repairing damaged DNA.

2024年10月2日 · Women who have a BRCA2 mutation have a 45% chance of developing breast cancer by the age of 70 (slightly lower than with a BRCA1 mutation). Men with a BRCA1 mutation also have a 1% risk of breast cancer, and a 6% risk with a BRCA2 mutation.

本文参考： 乳腺癌易感基因(breast cancer susceptibility gene, BRCA)与乳腺癌有着密不可分的关系。 BRCA基因 的两个成员，即BRCA1和2，分别是在1990年和1994年被分离。. 乳腺癌可以分为遗传性乳腺癌和散发性乳腺癌(sporadic breast cancer)，散发性乳腺癌指的是没有发现明确的遗传基因改变（完整的癌变点）与乳腺 ...

1998年9月4日 · BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a ...

2024年12月24日 · BRCA2 (BRCA2 DNA Repair Associated) is a Protein Coding gene. Diseases associated with BRCA2 include Breast Cancer and Fanconi Anemia, Complementation Group D1. Among its related pathways are Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) and Homologous DNA Pairing and Strand Exchange.

文章中，研究人员完成了对brca2关键dna结合结构域中所有可能性突变的全面功能评估，从而就能对该基因部分91%的不确定意义的突变进行临床分类 ...

2025年1月8日 · Results from a comprehensive evaluation of the function of BRCA2 variants, particularly variants of uncertain significance, provide a useful resource to improve the clinical management of ...