2004年11月15日 · Desmin is a muscle-specific protein and a key subunit of the intermediate filament in cardiac, skeletal and smooth muscles. Desmin filaments are mainly located at the periphery of Z-disk of striated muscles and at the dense bodies of smooth muscle cells, and they have been postulated to play a criti …

Desmin stain is a 52kDa cytoplasmic intermediate filament present in muscle and endothelial cells; expressed in neoplasms with myogenic differentiation

Desmin is a protein made by muscle cells. Non-cancerous and cancerous tumours made up of muscle cells also produce desmin.

Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF contributes to muscle structural and cellular integrity, force transmission, and mitochondrial homeostasis.

The present review uses a bibliometric approach to assess the research on desmin, and to compare its alleged functions. Based on the interpretation of the comparative list of functions we organized, we propose a new approach to interpret the function of desmin.

Desmin, the intermediate filament protein in striated muscle, is an essential component of the striated muscle cell cytoskeleton. In muscle, the cytoskeleton is a multifunctional, dynamic and complex structure that serves as a scaffold to maintain the structural integrity and architecture of the cardiomyocyte (CM).

2024年12月24日 · DES (Desmin) is a Protein Coding gene. Diseases associated with DES include Myopathy, Myofibrillar, 1 and Scapuloperoneal Syndrome, Neurogenic, Kaeser Type. Among its related pathways are Striated muscle contraction pathway and Cardiac conduction.

The DES gene provides instructions for making a protein called desmin. Desmin is found in heart (cardiac) muscle and muscles used for movement (skeletal muscle). Within muscle fibers, …

Desmin is a class-III IF protein and is one of the major IF proteins in cardiac and skeletal muscle. Mutations in the desmin gene cause desmin myopathy that presents as both muscular dystrophy and cardiomyopathy (Dalakas et al. 2000, Goldfarb et al. 1998).

Desmin is the muscle-specific member of the intermediate filament (IF) protein family. It is one of the earliest myogenic markers, both in heart and somites, and is expressed in satellite stem cells and replicating myoblasts.