2024年12月25日 · GSTM1 (Glutathione S-Transferase Mu 1) is a Protein Coding gene. Diseases associated with GSTM1 include Senile Cataract and Asbestosis. Among its related pathways are Metapathway biotransformation Phase I and II and Glutathione conjugation.

Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S -transferase. Cytosolic and membrane -bound forms of glutathione S -transferase are encoded by two distinct supergene families.

GSTM1 null genotype is associated with oral cancer development; GSTM1/GSTT1-double null genotype may be a risk factor for nasopharyngeal carcinoma among males in southern China.

2013年9月19日 · The gene for glutathione-S-transferase (GST) M1 (GSTM1), a member of the GST-superfamily, is widely studied in cancer risk with regard to the homozygous deletion of the gene (GSTM1 null),...

第一章谷胱甘肽硫转移酶mu1 (GSTM1)在肿瘤组织中低表达 GSTM1是GSTs家族成员之一,可以和还原性谷胱甘肽 (GSH)结合,发挥解毒作用,同时GSTM1也可以调节其他分子的活性,参与调节信号通路,进而调控细胞的增殖凋亡;并且其表达具有一定的组织特异性,在肝组织中表达最高.许多流行病学统计研究表明GSTM1的无效突变 (null mutation)与多种癌症的的易感性密切相关,但关于GSTM1在癌症发生中的作用机制尚未见报道,本研究首先利用收集的46例肝细胞癌标本,采用RT …

GSTM1 (glutathione S-transferase M1)，即谷胱甘肽硫转移酶M1，是负责多种致癌物质代谢的酶类家族GSTs中的一员。 GSTM1属于其中的µ类，其功能是使各类亲电子化合物，如药物、环境毒素、氧化链产物等与谷胱甘肽结合并进入下一步的代谢步骤。

该基因编码属于 mu 类的谷胱甘肽 S-转移酶。 mu 类酶通过与谷胱甘肽结合，在亲电子化合物 (包括致癌物、治疗药物、环境毒素和氧化应激产物) 的解毒中发挥作用。 编码 mu 类酶的基因组织在染色体 1p13.3 上的基因簇中，并且已知具有高度多态性。 这些遗传变异可以改变个体对致癌物和毒素的易感性，并影响某些药物的毒性和功效。 此类 mu 基因的无效突变与许多癌症的增加有关，这可能是由于对环境毒素和致癌物的易感性增加所致。 多种蛋白质亚型由该基因的转录变 …

2024年10月1日 · At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class.

2025年1月4日 · At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class.

HGNC Approved Gene Symbol: GSTM1. Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38) : 1:109,687,817-109,693,745 (from NCBI) The glutathione S-transferases (GST; EC 2.5.1.18) are a family of enzymes responsible for the metabolism of a broad range of xenobiotics and carcinogens (Mannervik, 1985).