Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets .

Thrombopoietin (TPO) is the physiologically relevant regulator of platelet production. Although the concept of a platelet growth factor analogous to erythropoietin had been proposed in the 1950s, it was not until 1994 that the existence of this hematopoietic growth factor was demonstrated and the protein purified [ 1-5 ].

血小板生成素(thrombopoietin, TPO)是有生理学意义的血小板生成调节因子。尽管1950年代就提出类似于促红细胞生成素(erythropoietin, EPO)的血小板生长因子的概念，但直到1994年才证实这种造血生长因子的存在，并提纯此蛋白质。

促血小板生成素（英語： Thrombopoietin ，縮寫爲「 THPO 」），亦作「巨核細胞生長衍生因子」（ MGDF ），是一種人體內由促血小板生成素（ THPO ）基因編碼的類激素。

2020年12月17日 · 促血小板生成素（英语： Thrombopoietin ，缩写为“ THPO ”），亦作“巨核细胞生长衍生因子”（ MGDF ），是一种人体内由促血小板生成素（ THPO ）基因编码的类激素。

Thrombopoietin, the primary regulator of blood platelet production, was postulated to exist in 1958, but was only proven to exist when the cDNA for the hormone was cloned in 1994. Since its initial cloning and characterization, the hormone has revealed many surprises.

Thrombopoietin (TPO) and its receptor, MPL, are the primary regulators of platelet production and critical for hematopoietic stem cell (HSC) maintenance. Since TPO was first cloned in 1994, the physiological and pathological roles of TPO and MPL ...

Thrombopoietin (TPO) is the principal physiologic regulator of platelet production. In vitro, TPO induces the growth of colony-forming units-megakaryocyte (CFU-MK) and the generation of mature polyploid megakaryocytes, which subsequently form extended cytoplasmic processes, termed proplatelets.

2024年3月6日 · 血小板生成素（thrombopoietin,TPO),与血小板疾病关系密切，TPO水平的检测对于血小板减少或增多的原因有鉴别诊断价值，而且可对某些疾病的药物治疗效果进行预测和评价。

Thrombopoietin (TPO) is the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. There is no "sensor" of the platelet count; rather TPO is produced in the liver at a constant …