Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. [5] . This gene is a member of the lectican (chondroitin sulfate proteoglycan) family.

Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the …

2002年3月1日 · Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure...

Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.

Aggrecan, a negatively charged proteoglycan, is a major macromolecular component of cartilage extracellular matrix. Like many biological macromolecules, the structure of aggrecan is uniquely tailored for its physiological function: it has a bottlebrush architecture and a semi-rigid character [1 – …

Aggrecans are proteoglycans composed of a protein (core protein) and glycosaminoglycan (GAG) chains that are covalently attached to the core protein (Fig. 8.2). The core protein of aggrecan has a molecular mass of approximately 230 kDa and consists of three globular domains (G1, G2, and G3) and two GAG attachment domains: the keratan sulfate ...

Aggrecans are the largest and most abundant “aggregating” proteoglycans in ECM and are formed by a high molecular weight (mw) (~250kDa) core protein linked to ~100 ChS and up to 60 KS chains. From: Nanomedicine: Nanotechnology, Biology and Medicine, 2016

2020年8月27日 · Aggrecan is a remarkably versatile and capable proteoglycan (PG) with diverse tissue context-dependent functional attributes beyond its established role as a weight-bearing PG.

Aggrecan is a large proteoglycan that has the important function of binding water due to the presence of negatively charged glycosaminoglycans (GAG). It is primarily found in intervertebral discs and cartilage, where it helps these tissues resist compressive loads by providing osmotic properties and swelling pressure.

key role in the biophysical and biomechanical properties of cartilage. Here, we review several approaches based on atomic force microscopy (AFM) to probe the physical, me. hanical, and structural properties of aggrecan at the molecular level. These approaches probe the response of aggrecan over a wide time.