Cyclins are generally very different from each other in primary structure, or amino acid sequence. However, all members of the cyclin family are similar in 100 amino acids that make up the cyclin box. Cyclins contain two domains of a similar all-α fold, the first located at the N-terminus and the second at the C-terminus. All cyclins are ...

2023年7月19日 · The cell cycle is regulated by cyclins, a type of protein that binds and activates cyclin dependent kinases (CDKs).

Cyclin F plays a role in cell cycle regulation through selective ubiquitination or binding of cell cycle proteins. • Cyclin F is involved in DNA synthesis and repair mechanisms, important in the context of genotoxic stress. • Cyclin F dysfunction has been linked to cancer, amyotrophic lateral sclerosis and frontotemporal dementia.

Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory enzymes involved in cell proliferation through regulating ...

A single cyclin A gene has been identified in Drosophila while Xenopus, mice and humans contain two distinct types of cyclin A: A1, the embryonic-specific form, and A2, the somatic form. Cyclin A1 is prevalently expressed during meiosis and early on in embryogenesis.

Coordinated protein phosphorylation reactions control progression through the cell cycle. Learn how specific complexes of cyclins and cyclin-dependent kinases (CDKs) catalyze these reactions.

Cyclins control cell cycle progression by regulating the activity of cyclin-dependent kinases (Cdks). Cyclin I is a member of the cyclin family because of the presence of a cyclin box motif. It has been suggested that Cyclin I is involved in various ...

2014年6月30日 · Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.

2021年11月1日 · The role of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as core components of the machinery that drives cell cycle progression is well established. Increasing evidence indicates that mammalian cyclins and CDKs also ...

Cyclins are a family of proteins that play a crucial role in the regulation of the cell cycle. They act as regulatory subunits of cyclin-dependent kinases (CDKs), forming complexes that drive the progression of cells through the different phases of the cell cycle.