Dedifferentiation (pronounced dē-ˌdi-fə-ˌren-chē-ˈā-shən) is a transient process by which cells become less specialized and return to an earlier cell state within the same lineage. [1]

2011年1月21日 · Dedifferentiation and transdifferentiation can be successfully achieved in vivo, and reprogramming facilitates genetic manipulation such as correcting disease-inducing mutations. The ultimate...

Dedifferentiation is a cellular process by which cells grow in reverse, from a partially or terminally differentiated stage to a less differentiated stage within their own lineage. In general, the phenomenon is manifested by a change in the shape, gene expression pattern, protein expression pattern and function.

2020年7月31日 · Dedifferentiation is a cellular process by which cells grow in reverse, from a partially or terminally differentiated stage to a less differentiated stage within their own lineage. In general,...

2014年8月18日 · We explored the underlying mechanisms of differentiation, dedifferentiation, reprogramming and transdifferentiation (cell type switchings) from landscape and flux perspectives.

Cell dedifferentiation is defined as the process in which cells undergo remarkable changes in gene expression, transitioning from a specialized function to a new program directing cell cycle reentry, cell death, or trans- or redifferentiation without passing through the cell cycle.

2021年7月21日 · Dedifferentiation refers to a cellular process in which a differentiated cell loses its special form or function, or reverts to an earlier developmental stage. Cell differentiation is a process in which the cell acquires modifications in form and function.

Recent advances have shown that the addition of a group of genes can not only restore pluripotency in a fully differentiated cell state (reprogramming) but can also induce the cell to proliferate (dedifferentiation) or even switch to another cell type (transdifferentiation).

2004年4月1日 · The remarkable regenerative capacity displayed by plants and various vertebrates, such as amphibians, is largely based on the capability of somatic cells to undergo dedifferentiation.

In this review we discuss the similarities between tumor dedifferentiation and somatic cell reprogramming and how this may pose a risk to the application of this new technology in regenerative medicine.