Desmosome is a intercellular junction in animal cell. A desmosome (/ ˈdɛzməˌsoʊm /; [1][2] "binding body"), also known as a macula adherens (plural: maculae adherentes) (Latin for adhering spot), is a cell structure specialized for cell-to- cell adhesion.

Apr 27, 2017 · Desmosomes are a type of anchoring junction in animal tissues that connect adjacent cells. Anchoring junctions are button-like spots found all around cells that bind adjacent cells together.

Desmosomes are specialized and highly ordered membrane domains that mediate cell-cell contact and strong adhesion. Adhesive interactions at the desmosome are coupled to the intermediate filament cytoskeleton.

Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate adhesion at desmosomes.

Desmosomes are one of four intercellular junctions present on the lateral side of neighboring polarized epithelial cells. Tight junctions and adherens junctions (AJs) are restricted to the apical domain, where they form the epithelial barrier and organize cortical actin, respectively.

Jul 26, 2011 · Desmosomes are specialized adhesive protein complexes that localize to intercellular junctions and are responsible for maintaining the mechanical integrity of tissues. The term ‘desmosome’ was coined by Josef Schaffer in 1920 and has its origins in the Greek words for bond (desmo) and body (soma).

Sep 1, 2021 · Desmosomes are intercellular junctions that anchor cell cytoskeletal intermediate filaments (IFs) and are responsible for maintaining tissue integrity, particularly in tissues that undergo mechanical stress such as the myocardium and epidermis (Fig. 1 A-C).

Aug 19, 2022 · Desmosomes have a highly organized, electron -dense structure. They are less than one μm in diameter and consist of three parts. They are composed of desmosome-intermediate filament complexes (DIFC), a network of cadherin proteins, linker proteins, and keratin intermediate filaments. A DIFC consists of three parts: 1.

Jan 24, 2022 · We review our current understanding of how desmosomal cadherins contribute to human health and disease, highlight gaps in our knowledge about their regulation and function, and introduce promising new directions toward combatting desmosome-related diseases.

Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins, which are grouped into desmogleins and desmocollins, are related to the ...