2022年12月22日 · A soluble-oligomer-binding assay captures α-sheet-containing peptides. SOBA detects Aβ oligomers in plasma from people with preclinical AD, MCI, and AD with 99 percent accuracy. A modified version of SOBA picks up α-synuclein oligomers in people with PD/LBD.

07 Jul 2022 It’s easy to blame soluble oligomers for whatever ails neurons, but it’s hard to isolate and characterize them. Now, scientists report a way to capture these nefarious species from biological fluids. As described in the July 7 Nature Chemistry, the method relies on a dual-affinity probe called Capture Molecule for Amyloid Precipitation. CAP-1 comprises two Pittsburgh …

03 Sep 2010 Oligomers of amyloid-β (Aβ) have created quite a stir since they were discovered to be perhaps the most toxic forms of the peptide. But oligomers are notoriously difficult to study. In fact, without much stirring, they spontaneously morph into larger and larger molecules that may be less germane to Alzheimer disease than their smaller counterparts. How is the researcher to …

Cummings agreed that a validated assay for Aβ oligomers in the CSF would aid development of treatments. Case in point, Alzhemed, aka homotaurine, aka tramiprosate, aka Vivimind, was recently revived once more in a new pro-drug formulation called ALZ-801.

2003年5月9日 · The antibody was similarly able to rescue cells from the toxic effects of other soluble oligomers, including insulin, IAPP, lysozyme, and polyQ proteins. One implication is that one antibody might be useful against a variety of amyloid disorders.

2011年10月26日 · When it comes to neurodegenerative diseases involving proteins that clump together, the consensus seems to be that small aggregates, or oligomers, are bad for cells, whereas larger ones, or amyloid fibrils, are less offensive. Although it’s not clear what the nasty oligomers actually look like or how they cause disease (see ARF Webinar ), few researchers …

2023年5月26日 · Others questioned whether T22 specifically recognizes oligomers in this context, since the antibody shows some affinity for tau filaments. “It is possible T22 recognized tau filaments in the synapses studied by Colom-Cadena et al.,” wrote Ryskeldi-Falcon. “Additional studies are required to identify the molecular species of tau present in synapses in the brains …

14 Oct 2023 Neurofibrillary tangles, the hallmark of tauopathies, are closely linked to failing cognition. So are tau oligomers, suggest scientists led by Teresa Gómez-Isla at Massachusetts General Hospital in Boston. In the October 9 JAMA Neurology, they reported that, in people with Alzheimer’s disease, synapses were packed with the oligomers and there were fewer of them …

2016年5月6日 · The oligomers’ structures remained stable throughout the procedure, Esparza believes, because they had the same size according to size-exclusion chromatography in the initial lysates and final purified preparation. No new oligomers formed; Esparza confirmed this by spiking in monomers, which stayed monomers.

2023年2月6日 · The middle dose produced the highest brain levels of compound, and reduced soluble tau oligomers, as well as insoluble and phosphorylated tau in brain, compared to untreated mice (Davidowitz et al., 2020).