Translational research (also called translation research, translational science, or, when the context is clear, simply translation) [1] [2] is research aimed at translating (converting) results in basic research into results that directly benefit humans.

Translational research transforms findings made in the preclinical laboratory, clinic, and community into interventions that improve the health of individuals and the public — from diagnostics and therapeutics to medical procedures and behavioral changes. But that process is far from straightforward and is often subject to a variety of ...

The meaning of TRANSLATION is an act, process, or instance of translating. How to use translation in a sentence.

Translational research seeks to produce more meaningful, applicable results that directly benefit human health. The goal of translational research is to translate (move) basic science discoveries more quickly and efficiently into practice.

What is Translational Research? In clinical and translational research, scientific discoveries are moved along a virtual path from the laboratory into real-world practice, leading to improved human health.

Translational research was designed for the medical world. It emerged in response to concern over the long time lag between scientific discoveries and changes in treatments, practices, and health policies that incorporate the new discoveries. …

2025年1月22日 · Translational science focuses on understanding the scientific principles underlying each step of the translational process. Last updated on January 22, 2025. The spectrum represents the stages of research involved in …

Translational medicine has yet to deliver on its vast potential. Obstacles, or “blocks,” to translation at three phases of research have impeded the application of research findings to clinical needs and, subsequently, the implementation of newly developed interventions in patient care.

We want everyone to know what translational science is and have an understanding of the general scientific and operational principles of translation–the process of turning observations into interventions that improve patients’ lives.

2024年12月28日 · Translational science, also known as translational research, is a multifaceted approach that seeks to accelerate the translation of scientific discoveries into practical applications that benefit human health.

Translational Science identifies barriers to the advancement of research across the translational spectrum, works toward a product or approach that overcomes or mitigates that barrier, and is generalizable across multiple diseases/conditions.

Translational research involves moving knowledge gained from the basic sciences to its application in clinical and community settings. This concept is often summarized by the phrases “bench-to-bedside” and “bedside-to-community” research.

Phase T1 translational research involves work that develops concepts and discoveries from basic research through early phase clinical trials in humans. 7 Drug development, some studies of disease mechanisms, including proteomics, genomics, genetics, metabolomics, and animal models, are examples of T1 phase translational research. Other examples include …

Translational medicine is a medical practice based on interventional epidemiology. It is regarded by its proponents as a natural progression from Evidence-Based Medicine.

2025年1月22日 · Translation is the process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public — from diagnostics and therapeutics to medical procedures and behavioral changes.

Translational medicine (often called translational science, of which it is a form) develops the clinical practice applications of the basic science aspects of the biomedical sciences; that is, it translates basic science to applied science in medical practice.

Translational science is a disease-agnostic approach to understanding common causes of inefficiency and failure in research. It seeks to develop innovative solutions to enhance the efficiency and effectiveness of all translational research and ultimately benefit research across a range of diseases and conditions.

Translational research is 'the process of applying ideas, insights, and discoveries generated through basic scientific inquiry to the treatment or prevention of human disease'. The philosophy of 'bench to bedside' underpins the concept of translational medicine, ie.

Translational science is the process of turning observations in the laboratory, clinic, and community into interventions that improve the health of individuals and populations.

Translational research does what it says on the tin: it takes findings from controlled clinical studies – so-called ‘bench to bedside’ research – and seeks to translate them to real-world community or health settings.

4 天之前 · Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments before they proceed to human clinical trials. However, given the intricate nature of human physiology and the complexities of diseases such as cancer, this paper critically examines the role of animal experimentation in translational …

In co-translational translocation, the entire ribosome–mRNA complex binds to the outer membrane of the rough endoplasmic reticulum (ER), and the new protein is synthesized and released into the ER; the newly created polypeptide can be immediately secreted or stored inside the ER for future vesicle transport and secretion outside the cell.

6 天之前 · To gain global insights into ribosome activity, ribosome profiling (Ribo-Seq) has become increasingly popular to determine the translational efficiency of mRNAs and detect non-canonical open ...